Recent Studies on Aromatase and EGFR Involved in Breast Cancer and their Inhibitors

Document Type : Review articles


1 Pharmaceutical chemisrty department, faculty of pharmacy , delta university for science and technology , Gamasa

2 Organic chemistry, faculty of pharmacy , mansoura university

3 Organic chemistry department, faculty of pharmacy, Mansoura University


One of the major issues affecting worldwide public health in cancer .According to the related occurrence and morbidity statistics, it is becoming more commonin both economically developed and developing countries.. several diagnostics procedures and early treatment methods are essential to reduce the incidence rate of breast cancer. In this article, we introduce several reported strategies of treatment based on the tumor progression and breast cance Subtypes to offer the most personalized treatment for BC patients.
According to Global Cancer Observatory (GLOBOCAN), a web-based platform presenting global cancer statistics, breast cancer in 2020 is currently one of the most frequently diagnosed malignancies and the fifth cause of cancer-related deaths, with approximately 2.3 million new cases worldwide and is now also the leading cause of cancer death among females in economically developing countries compared to the developed ones. One in eight American women will have breast cancer at some point in their lives, according to the American Cancer Society .
In 2023, about 297,790 new cases of invasive breast cancer will be diagnosed in women. By 2050, there are projected to be 3.2 million new incidences of breast cancer year worldwide. These statistics illustrate the severity of the breast cancer incidence, which will have an impact on society in general and require immediate preventive measures .
The Breast Health Global Initiative (BHGI) is currently in charge of creating appropriate recommendations and strategies to give the most effective breast cancer control achievable around the world .


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